Season 4

After engineering a daring escape from the hellish, Panamanian prison Sona, brothers Michael Scofield and Lincoln Burrows are determined to seek justice against The Company, the shadowy group responsible for destroying their lives and killing the woman Michael loves, Dr. Sara Tancredi. Michael’s quest for vengeance leads him to Los Angeles, where his world is turned upside down when Company operative Gretchen/Susan B. Anthony informs him that Sara is still alive. Realizing the only way they will truly be free, Michael and Lincoln avow to find Sara and take down The Company. With the help of Homeland Security agent Don Self, they assemble a group of allies and familiar faces to accomplish their task: Mahone, Sucre, Bellick and computer expert Roland Glenn. Unfortunately for the brothers, they must also evade company assassin Wyatt and find an on-the-loose T-Bag. Michael and Lincoln soon discover the only thing harder than breaking out will be breaking in.

• 22 episodes
• First aired Sept. 1, 2008

Episodes

• 1
  Scylla Sept. 1, 2008
• 2
  Breaking & Entering Sept. 1, 2008
• 3
  Shut Down Sept. 8, 2008
• 4
  Eagles and Angels Sept. 15, 2008
• 5
  Safe and Sound Sept. 22, 2008
• 6
  Blow Out Sept. 29, 2008
• 7
  Five the Hard Way Oct. 6, 2008
• 8
  The Price Oct. 20, 2008
• 9
  Greatness Achieved Nov. 3, 2008
• 10
  The Legend Nov. 10, 2008
• 11
  Quiet Riot Nov. 17, 2008
• 12
  Selfless Nov. 24, 2008
• 13
  Deal Or No Deal Dec. 1, 2008
• 14
  Just Business Dec. 8, 2008
• 15
  Going Under Dec. 15, 2008
• 16
  The Sunshine State Dec. 22, 2008
• 17
  The Mother Lode April 17, 2009
• 18
  VS. April 24, 2009
• 19
  S.O.B. May 1, 2009
• 20
  Cowboys and Indians May 8, 2009
• 21
  Rate of Exchange May 15, 2009
• 22
  Killing Your Number May 15, 2009

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